Glynase XL 5 mg Tablet

Glynase XL 5 mg (Glipizide)

Uses of Glynase XL 5 mg (Glipizide)

Glynase XL 5 mg is used to lower the blood sugar level in patients with Type-2 diabetes mellitus that is not controlled by diet and exercise alone.

How it works

Glynase XL 5 mg belongs to a class of medicines called sulphonylurea. Glynase XL 5 mg acts by promoting insulin secretion in the body, so that the blood sugars are utilized by various organs, leading to a fall in blood levels of sugar.

What is glipizide?

Glipizide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin. It is used together with diet and exercise to treat type 2 diabetes. It may also be used for purposes not listed in this medication guide.

Important information

You should not use glipizide if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glipizide, tell your doctor if you have kidney or liver disease, chronic diarrhea or a blockage in your intestines, glucose-6-phosphate dehydrogenase deficiency (G6PD), a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished.

Glipizide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Before taking this medicine

You should not use this medicine if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure glipizide is safe for you, tell your doctor if you have:

• Liver or kidney disease;
• Chronic diarrhea or a blockage in your intestines;
• An enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
• A disorder of your pituitary or adrenal glands;
• A history of heart disease; or
• If you are malnourished.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking glipizide.

It is not known whether glipizide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether glipizide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take glipizide?

Take glipizide exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take glipizide 30 minutes before a meal. If you take this medicine once daily, take it 30 minutes before breakfast.

Glipizide extended-release (Glucotrol XL) should be taken with breakfast.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor?s advice.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor?s office.

Some forms of glipizide are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medication less effective.

Glipizide is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor?s instructions very closely.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose 30 minutes before your next meal, then return to your regular schedule. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Use glipizide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while taking glipizide?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

If you also take colesevelam, avoid taking it within 4 hours after you take glipizide.

Common side effects

• Nausea,
• Itchy rash,
• Abdominal pain,
• Jaundice,
• Abnormal liver function tests,
• Blurred vision,
• Diarrhoea,
• Dizziness,
• Fall in blood sugar level,
• Sleepiness,
• Tremor,
• Vomiting

Expert advice for Glynase

• Do not take glipizide, if you have type 1 diabetes mellitus or have had impaired consciousness due to severe diabetes, liver or kidney disease, or deficiency of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).
• Do not take glipizide, if you are pregnant or breast-feeding.
• Do inform your doctor, if you are about to have major surgery or have had a recent injury (trauma) or develop a fever or severe infection.
• Do not drive or operate machinery, if you have just started taking glipizide as it may cause excessive fall in the blood sugar level leading to the following symptoms: confusion, faintness, sweating, dizziness, drowsiness, headache shakiness (tremor) and visual disturbances.

Frequently asked questions for Glynase

Glipizide

Q: Can you take glipizide with sulfa allergy?
You can take glipizide if you are not allergic to glipizide or drugs from the same class i.e. sulphonylureas, sulphonamides or to any ingredients of the glipizide table. Glipizide is not contraindicated in patient with sulfa allergy.

Q: Can you take glipizide with or without metformin?
A: You can take glipizide with or without metformin. However, always follow doctor?s advice regarding its use.

Q: Can I take glipizide with insulin?
A: Yes. However, always follow doctor?s advice regarding its use.

Q: Can I take glipizide with levothyroxine?
A: When levothyroxine is taken with glipizide, it may compromise the blood sugar controlling effect of glipizide. However, levothyroxine and glipizide can be taken together at a dose and schedule advised by your doctor.

Q: Can I take glipizide with paracetamol?
A: Glipizide and paracetamol have no known adverse drug interactions and can be taken together. However, always follow doctor?s advice regarding its use.

Q: Can I take glipizide with ibuprofen?
A: Concomitant administration of glipizide with ibuprofen may cause excessive lowering of the blood sugar level (hypoglycemia).Ibuprofen can be taken with glipizide if indicated provided that you follow the advice of the doctor regarding the dose and schedule of use of drugs.

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