INTRODUCTION

nHISONE 20MG contains Hydrocortisone which belongs to the group of medicines called corticosteroids. It can be used as a replacement therapy for endogenous corticosteroids in children suffering from insufficient production of corticosteroids due to congenital adrenal hyperplasia, adrenal insufficiency or doubtful adrenocortical reserve. It can also be used for adding hydrocortisone after surgeries, trauma, injuries or other stressful conditions. It is also used to treat severe asthma and other allergic reactions or serious illness in both adults and in children.
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nCorticosteroids are the substance that naturally produced in your body and helps to maintain your health and well-being. Supplementing your body with extra corticosteroids can help to treat various illnesses and inflammatory conditions. Hydrocortisone binds to the corticosteroid receptors of adrenal glands and mediates various physiological functions. It also blocks the production of various inflammatory mediators responsible for causing inflammation and allergies.
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nHISONE 20MG can be taken with or without food. Do not reduce the dose or stop taking this medicine without informing your doctor, as it may result in withdrawal symptoms such as muscle/joint pain, fever and general discomfort. At the same time, do not take too much of this medicine, because it can lead to overdosage. Symptoms of overdosage includes nausea, vomiting, fluid retention, high blood sugar or GI bleeding.
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nWhile taking this medicine, inform your doctor immediately if you experience any signs of mental problems such as depression or suicidal thoughts. Your doctor might reduce your dose or suggest an alternative therapy. Stay away from people having chickenpox, shingles or measles, because infections are easier to get and harder to spot while taking HISONE 20MG.
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nDo not take this medicine if you have any bacterial, viral or fungal infections. Before taking this medicine inform your doctor if you have any liver, kidney, heart or stomach problems. While giving this medicine to premature infants and children, proper dose titration and careful monitoring of heart function and growth are required. Pregnant and breastfeeding women should inform their doctor before taking HISONE 20MG as a precaution.
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USES OF HISONE 20MG

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• Used as a replacement therapy for corticosteroid deficiency in children with congenital adrenal hyperplasia, adrenal insufficiency or doubtful adrenocortical reserve

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• Supplements corticosteroids during or after surgeries, trauma, injuries or other stressful conditions in adults and in children

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• Treat severe asthma and other allergic reactions in both adults and in children

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HOW HISONE 20MG WORKS

nHydrocortisone is a corticosteroid hormone receptor agonist. It binds to the corticosteroid receptors of adrenal glands and mediates various physiological functions such as gluconeogenesis, protein catabolism, renal excretion of calcium and capillary wall stability. It also works by inhibiting the production of various inflammatory mediators and chemical messengers which are responsible for causing inflammation (redness and swelling) and allergies (asthma, hay fever).
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DIRECTIONS FOR USE

nTake HISONE 20MG as directed by your physician. It can be taken with or without meals. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
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SIDE EFFECTS OF HISONE 20MG

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HOW TO MANAGE SIDE EFFECTS

nMental health problems:
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nThis is a common side effect in both adults and in children and need to be monitored very carefully. Contact your doctor immediately if you experience any signs of mental problems such as depression or suicidal thoughts. Your doctor might reduce your dose or suggest an alternative therapy.
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WARNING & PRECAUTIONS

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INTERACTIONS

nTalk to your doctor, if you are taking
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• Medicines used to treat epilepsy (e.g. phenytoin, phenobarbital, carbamazepine and primidone)

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• Ephedrine (a decongestant used to treat cold and cough)

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• Medicines used to treat tuberculosis (e.g. rifabutin or rifampicin)

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• Medicines used for blood thinning (e.g. warfarin)

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• Medicines used to treat fungal infections (e.g. amphotericin and ketoconazole)

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• Medicines used to treat heart failure (e.g. digoxin, furosemide or bumetanide), high blood pressure (e.g. atenolol, captopril) or other heart disease (e.g. guanethidine, hydralazine, isosorbide mononitrate, isosorbide dinitrate and theophylline)

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• Sympathomimetics (used to treat cold and cough, asthma or low blood pressure) such as bambuterol, fenoterol, formoterol, ritodrine, salbutamol, salmeterol, terbutaline

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• Non-steroidal anti-inflammatory drugs (used to treat pain and inflammation) such as ibuprofen, diclofenac or naproxen

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• Medicines used to treat diabetes (e.g. insulin, metformin)

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• Aspirin (used to treat pain and blood clotting)

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• Diuretics (used to increase urine output) e.g. furosemide

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• Aminoglutethimide (used to treat cancer)

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• Erythromycin (used to treat bacterial infection)

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• Oral contraceptive pills (birth control pills)

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• Hormone replacement therapy

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• Somatropin (a hormone used to increase growth)

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• Calcium supplements

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• Sodium phenylbutyrate (used to correct disorders of urea cycle)

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• Ritonavir and cobicistat (a synergistic combination used to treat HIV infection)

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• Methotrexate (used to treat cancer or rheumatoid arthritis)

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• Ciclosporin (used to treat psoriasis or prevent graft rejection)

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• Minoxidil (used to increase hair growth)

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MORE INFORMATION

nStore below 20-25°C and keep out of reach of children.
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FAQ’s ABOUT HISONE 20MG

nQ: Is HISONE 20MG a steroid?
nA: Yes. This medicine is a corticosteroid use to treat various allergic and inflammatory conditions and metabolic disorders.
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nQ: Is HISONE 20MG safe during pregnancy?
nA: Consult your doctor before taking any medicine if you are pregnant or think you may be pregnant. Your doctor will decide whether you should take this medicine or not depending upon the severity of the disease.
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nQ: What happens if I take too much of this medicine?
nA: Take this medicine only as directed by your physician. If you or anyone accidentally took too much of this medicine contact your doctor immediately. Symptoms of overdosage might include nausea, vomiting, fluid retention, high blood sugar or GI bleeding.
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nQ: Is HISONE 20MG addictive?
nA: This medicine is not habit-forming in nature, but it may cause withdrawal symptoms such as muscle/joint pain, fever and general discomfort if the dose is reduced or stopped abruptly. In such cases, contact your doctor.
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